Linking vitamin D to lower risk

In this analysis, researchers reviewed data from 17 studies that included more than 13,000 participants, and looked at how much vitamin D people consumed through diet and supplements and examined whether there is a link between vitamin D blood levels and the risk of colorectal cancer. Blood levels of vitamin D were determined by measuring 25-hydroxyvitamin D.

Results showed:

• People with the highest vitamin D intake had a 12% lower risk of colorectal cancer and people with the highest blood levels had a 33% lower risk, compared with people with the least intake and the lowest blood levels.
• Higher vitamin D was linked to an equal lowered risk for both colon cancer and rectal cancer.

“Vitamin D deficiency is considered an important risk factor for many types of solid cancers, especially colorectal cancer,” commented the study authors. “Among patients with colorectal cancer, the prevalence of vitamin D deficiency is much higher, approaching 90%, than among other patients. A few studies have demonstrated that vitamin D may decrease the risk of cancer through various mechanisms.”

Keep in mind that since the studies reviewed in this report were observational, they do not prove cause and effect. But they suggest an interesting association, which should be explored further through randomised, controlled trials.

Take Action

• Know your vitamin D levels. Talk with a doctor about the benefits of having your vitamin D level checked to find out whether you are getting enough vitamin D. If your doctor determines that your levels are low, talk about how to optimize vitamin D intake and whether or not a vitamin D supplement is appropriate for you.
• Get your vitamin D. Vitamin D may come from exposure to sunshine, through the diet or through supplements. Food sources include vitamin D–fortified drinks and oily fish such as salmon and mackerel.
• Take preventive steps. Many people could help prevent colorectal cancer through healthy lifestyle behaviours and routine preventive screenings,such as having your stool checked for blood and regular colonoscopies. To help optimize your health and prevent disease, talk with a doctor about preventive steps recommended for your age and medical history.

(J Clin Oncol 2011. 10.1200/JCO.2011.35.7566)