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In this study, 146 overweight or obese veterans (72% men) were randomly assigned to follow a low-carbohydrate diet (initially less than 20 grams per day) or daily orlistat therapy plus a low-fat (less than 30% of daily energy), reduced-calorie diet. During the 48-week study, both groups attended small group sessions every 2 to 4 weeks where they were counseled about their diet and other nutritional topics. All participants were instructed to exercise at least 30 minutes three times a week. The study examined the effects of each diet on body weight and metabolism. Results showed:
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(Arch Intern Med 2010;170:136–45.)
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